Regulation of Superoxide Dismutase ( sod ) Genes by SarA in Staphylococcus aureus
نویسندگان
چکیده
منابع مشابه
Superoxide dismutase activity in thermally stressed Staphylococcus aureus.
The effects of heat and NaCl on the activity of superoxide dismutase from Staphylococcus aureus were examined. A linear decrease in superoxide dismutase activity occurred when S. aureus MF-31 cells were thermally stressed for 90 min at 52% C in 100 mM potassium phosphate buffer (pH 7.2). After 20 min of heating, only 5% of the superoxide dismutase activity was lost. Heating for 60, 90 and 120 m...
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The staphylococcal accessory regulator locus (sarA) encodes a DNA-binding protein (SarA) that modulates expression of over 100 genes. Whether this occurs via a direct interaction between SarA and cis elements associated with its target genes is unclear, partly because the definitive characteristics of a SarA binding site have not been identified. In this work, electrophoretic mobility shift ass...
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In S. aureus, the production of virulence determinants such as cell wall adhesins and exotoxins during the growth cycle is controlled by global regulators such as SarA and agr. Genomic scan reveals 16 two-component regulatory systems (e.g. agr and sae) as well as a family of SarA homologs in S. aureus. We call the SarA homologs the SarA protein family. Many of the members in this protein family...
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The proteins encoded by the intercellular adhesin genes (icaADBC) synthesize the polysaccharide poly-N-acetylglucosamine (PNAG), which contributes to the formation of a biofilm by Staphylococcus aureus. In addition to the proteins that synthesize PNAG, the ica locus also encodes the TetR family transcriptional regulator IcaR (23). The icaR gene is transcribed divergently from icaADBC (10) and i...
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The advent of transcription profiling technologies has provided researchers with an unprecedented ability to study biological processes. Accordingly, a custom-made Affymetrix GeneChip, constituting >86% of the Staphylococcus aureus genome, was used to identify open reading frames that are regulated by agr and/or SarA, the two best-studied regulators of the organism's virulence response. RNA ext...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2009
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01496-08